Spravato: A Promising Treatment Option

At Ketamine Wellness Infusions PA, we understand how challenging it is to navigate the mental health treatment landscape.

One promising treatment option we’re happy to offer our patients is Spravato. Spravato is a prescription medication and brand name for esketamine, an FDA cleared drug derived from ketamine that helps alleviate symptoms of treatment-resistant depression (TRD).

If you’re unfamiliar with ketamine treatments, we can provide information on esketamine, its advantages, and how it distinguishes itself from ketamine infusions.

Our compassionate team is here to guide you through this journey towards healing and hope.

What is Esketamine?

Esketamine is a prescription medication that belongs to the NMDA receptor antagonist class. This substance originates from ketamine, a well-known anesthetic.

When administered by a skilled healthcare provider, ketamine boosts the functioning of a chemical messenger known as glutamate. Increased glutamate levels improve one’s emotional state and reducing symptoms of anxiety or depression.

Esketamine is a nasal spray used mainly to treat treatment-resistant depression (TRD), in contrast to ketamine infusions which are given intravenously.

Esketamine vs. Ketamine:

Ketamine infusions and esketamine nasal spray differ in how they are given to patients.

Patients can administer esketamine intranasally on their own under supervision of a healthcare provider and typically requires 30 minutes of downtime.

Ketamine infusions require a trained medical professional to administer an IV to start the treatment. Infusions usually last about an hour with 30 minutes of downtime.

Patients can not drive after either treatment.

Some side effects of esketamine nasal spray are:

  • Fatigue
  • Nausea
  • Dissociation
  • Increased blood pressure

Side effects of ketamine infusions are similar, but can also vary:

  • Fatigue
  • Nausea
  • Pain around injection site
  • Loss of appetite

One final difference between esketamine vs. ketamine infusions is FDA approval.

Spravato is FDA for treatment-resistant depression since 2019. Ketamine infusion therapy is not FDA approved and considered off-label.

Spravato Insurance Coverage:

Insurance coverage for esketamine is a concern for many patients.

Since it’s still a relatively new treatment method, some insurance plans may not cover it.

We encourage patients to work with their insurance providers to determine their eligibility for coverage.

Many insurance companies are becoming aware of the therapeutic value of esketamine treatment and are expanding their coverage options.

Benefits of Esketamine:

Esketamine provides new hope for individuals struggling with treatment-resistant depression.

The drug’s rapid onset of action can take as little as a few hours to show results, unlike traditional antidepressants that can take several weeks.

This rapid response can be very beneficial for patients experiencing severe or suicidal depression.

When combined with traditional treatment methods such as cognitive behavioral therapy, estketamine nasal spray has been shown to reduce symptoms, improve overall mood, and increase well-being.

Many patients report significant improvements in their functioning, reduced lethargy, and enhanced quality of life.

Esketamine Treatment Center: Ketamine Wellness Infusions PA


Esketamine is an exciting and promising treatment option for individuals with treatment-resistant depression.

Our compassionate team at Ketamine Wellness Infusions PA is here to guide you through this journey towards healing and hope. Understanding the differences between esketamine and ketamine infusions, navigating insurance coverage, and the benefits it offers are crucial to making informed decisions.

Our mission is to help you discover your potential for resilience, growth, and transformation.

Contact our team for a consultation today.


Ketamine Can Help Treat The Following Conditions



Ketamine has been found to relieve the symptoms of depression within hours, rather than the usual weeks most antidepressants can take.

Ketamine Wellness Infusions


Those suffering from PTSD after one or more traumatic events may find relief with Ketamine Infusion Treatment.


 Postpartum Depression

Ketamine offers rapid relief for those suffering from postpartum depression.

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Ketamine is highly effective for major depressive disorder and recommended as adjunctive therapy for patients with bipolar depression.


Neuropathic Pain

Ketamine has been shown to help reset nerve connections throughout the body, relieving the symptoms of neuropathy.

Ketamine Wellness Infusions


Patients have been finding relief from the pain and symptoms of migraines with the advent of Ketamine Infusion Treatment.


Opioid Resistant Cancer Pain

Ketamine is an effective treatment for cancer patients living with opioid resistant pain.

Ketamine Wellness Infusions


Ketamine gives new hope to many living with Fibromygalgia. By blocking the activity of the NMDA receptor, ketamine seems to reset the altered pain receptors.



Ketamine is an exceptional option for treating suicidality because it produces essential, quick results.

Ketamine Wellness Infusions


Ketamine infusion treatments has been found to be helpful for relieving the obsessions of OCD.



Ketamine has found success relieving the symptoms of anxiety and panic in those suffering from these conditions.

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